In Vitro ADMET

Early in vitro ADME screening to characterise Absorption, Distribution, Metabolism, Excretion (ADME) and Pharmacokinetics (PK) properties of lead compounds is critical for elucidating desirable drugability profiles.

In vitro ADMET

  • Solubility : Kinetic, Equilibrium
  • Plasma Protein Binding: Mouse, Rat, Dog, Human
  • Permeability : PAMPA, Caco2 (Unidirectional, Bidirectional)
  • Microsomal Metabolic Stability: Mouse, Rat, Dog, Human
  • Human CYP450 assays: Inhibition, Isoform Phenotyping
  • Cytotoxicity : HepG2, A549, MDCK cell lines