In vitro ADMET

  • Solubility : Kinetic, Equilibrium
  • Plasma Protein Binding: Mouse, Rat, Dog, Human
  • Permeability : PAMPA, Caco2 (Unidirectional, Bidirectional)
  • Microsomal Metabolic Stability: Mouse, Rat, Dog, Human
  • Human CYP450 assays: Inhibition, Isoform Phenotyping
  • Cytotoxicity : HepG2, A549, MDCK cell lines

Pharmacokinetics (PK)

  • Systemic and oral PK
  • Dose escalation and Repeat dose PK
  • Tissue distribution
  • Oral Bioavailability: Absolute and Relative
  • Bioequivalence



Modelling and Simulation

  • Modelling PK: NCA, Compartment, PBPK models
  • PK/PD Modelling
  • Simulation of "what-if" scenarios with PK, PD and PK/PD models
  • Prediction of Human PK : Allometry, PBPK


theme-img"Where science and responsible animal care connect."