In vitro ADMET

  • Solubility : Kinetic, Equilibrium

  • Plasma Protein Binding: Mouse, Rat, Dog, Human

  • Permeability : PAMPA, Caco2 (Unidirectional, Bidirectional)

  • Microsomal Metabolic Stability: Mouse, Rat, Dog, Human

  • Human CYP450 assays: Inhibition, Isoform Phenotyping

  • Cytotoxicity : HepG2, A549, MDCK cell lines

Pharmacokinetics (PK)

  • Systemic and oral PK

  • Dose escalation and Repeat dose PK

  • Tissue distribution

  • Oral Bioavailability: Absolute and Relative

  • Bioequivalence

Modelling and Simulation

  • Modelling PK: NCA, Compartment, PBPK models

  • PK/PD Modelling

  • Simulation of "what-if" scenarios with PK, PD and PK/PD models

  • Prediction of Human PK : Allometry, PBPK